I have a long time to wait. I just did a retest last week because mine came back inconclusive!! Unlike most DNA, which is found inside a cell's . Meet other parents of January 2020 babies and share the joys and challenges as your children grow. Be sure to understand what the test screens for and what the results mean so you make an informed decision. DNA makes up a persons genes and chromosomes, and gives healthcare providers a glimpse into the fetuss genetic makeup. Press question mark to learn the rest of the keyboard shortcuts, third time mom / due aug 2023 / 30 / she/her. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. What was the outcome? I had the first done at 13w and second done at 16w. It doesn't mean anything else (good or bad). Amnio specialist also told me that low fetal fraction can be because of placenta. If your baby still has a heartbeat now, maybe that means that the baby doesnt have that. Anyone else go through this and get good results? Hey lovely - where are you based? I ended up asking for a quad screen (it wasnt covered by my insurance but was like $30) to assess risk for trisomy 21, 18 and spina bifida. 0 9500 Euclid Avenue, Cleveland, Ohio 44195 |, (https://www.acog.org/womens-health/faqs/prenatal-genetic-screening-tests), (https://www.acog.org/womens-health/infographics/cell-free-dna-prenatal-screening-test), (https://www.cdc.gov/ncbddd/birthdefects/diagnosis.html). What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. hb``c``Zp7XX8LN`` NIPT test done twice.with inconclusive results twice. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. My next appt is my anatomy scan and it isnt until Nov 30! The most common sex chromosome conditions are Turner syndrome, Klinefelter syndrome, Triple X syndrome and XYY syndrome. It requires drawing blood from the pregnant person only. But that's my personal non-expert opinion. Use of this site is subject to our terms of use and privacy policy. Group Black's collective includes Essence, The Shade Room and Naturally Curly. A place for pregnant redditors, those who have been pregnant, those who wish to be in the future, and anyone who supports them. They told me since I am now 16w, I can send the quad screen to test for the trisomies and spina bifida. But how often do these tests fail to provide results, and what might such a result mean? Cleveland Clinics Ob/Gyn & Womens Health Institute is committed to providing world-class care for women of all ages. Inconclusive NIPT twice! NIPT Sex chromosome aneuploidy or fetal sex inconclusive You recently had a blood test to screen for chromosome disorders in the fetus and were told: amount of DNA is from the pregnancy. Friend opening my baby items for their own baby. We strive to provide you with a high quality community experience. I'm pretty sure its because I'm overweight lolmanyjow dehydration sounds like a good idea although the first day I went I had puked all morning Anyhow am skipping it now and will just wait till my next appointment which is on the 20th and hopefully we will find out the gender. We had two inconclusive NIPT tests (from two different testing companies). NIPT tests dont diagnose conditions. However my 12 weeks NT scan and EFTS blood test both came back normal/ low . Not all NIPT panels evaluate for the same conditions. Good luck!! Cleveland Clinic is a non-profit academic medical center. Guess how I found that out? The #1 app for tracking pregnancy and baby growth. This time around I used Myriad Prequel, which has a technology that prevents most (maybe all?) Can I ask how your Quad screening went? Learn more about, Twins & Multiples: Your Tentative Time Table. I dont think Im obese but definitely considered overweight. This educational content is not medical or diagnostic advice. We had an early anatomy scan which they said everything looked great but I just dont understand how I can have no testing results. Hope you are getting all the support you need and sending good healthy babe energy your way! This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. Has anyone had the test come out inconclusive twice? I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. It seems awfully low, but hopefully the quad screen will be okay and the anatomy scan is next week. So relieved! Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Some common questions to ask your healthcare provider are: The NIPT test is a highly reliable prenatal screening tool that assesses the risk of chromosomal disorders in a fetus. endstream endobj 73 0 obj <>stream Same thing happened to me. They tell your provider how likely it is that a condition exists. If my screening test is positive, what are the next steps? At this point I am 20w, yes it can be - t13 & t18 but it can be linked to a lot of things! And if so, what are you going to do? This happened to me as well. You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). Which is less than it would normally be for my age. Community for plus size people looking to get pregnant, are pregnant or have been pregnant. (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3893900/). Luckily the last vile came back (after 25 days) and everything was fine! NIPT doesnt test for all chromosomal conditions or birth disorders. Has anyone experienced this? They didnt find anything wrong. Ans to top it off I really wanted to find out the gender and now I dont even know if things are ok. Results from NIPT tests can sometimes take up to two weeks, although results are often available sooner. 69 0 obj <> endobj 20062023 BabyCenter, LLC, a Ziff Davis company. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. Are you tall? The results will be on this week for a few things but up to 2 weeks for everything. Reasons behind an inconclusive prenatal paternity test. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. It's not like my weight was a surprise to them. Cell free DNA screening is not a simple blood test. I fully understand your need for answers - I felt exactly the same way and its much better to have a yes/no answer through CVS/amniocentesis than keep guessing etc. This happened to me as well. I'm panicking now because I'm so worried. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. you can always do amnio if you need results. the most helpful and trustworthy pregnancy and parenting information. your experiences with being fat an needing IVF/ICSI? Find advice, support and good company (and some stuff just for fun). This pregnancy has been so stressful so far 0 We are going to pursue that because of the rarity of not presenting a result initially. Would you get the NIPT test if you were me? I realize I may have been taking about something different. Your healthcare provider will provide information about prenatal genetic testing and help you make an informed choice about your options. Noninvasive pregnancy screening tests are a personal choice. Overwhelmed and frustrated by weight gain. Noninvasive prenatal testing: the future is now. I would be very frustrated. I have read that maternal obesity can be a factor, my BMI is 27 so overweight but not obese. Im so so very sorry. Is a genetic counselor available to talk to me about my options? NIPT is a screening test and, therefore, isnt perfect. Have a child with a chromosomal abnormality. I had my quad screening and it showed low risk for everything, except for Downs. Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. The blood sample is sent to a lab and analyzed for specific congenital disorders. Get useful, helpful and relevant health + wellness information. No idea what that means. I have never heard of two inconclusive results! Originally my doctor said we would take another blood sample once I was further along around 16 weeks and try again if it didn't work initially. The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? Now doing the waiting game!! It does have a lower accuracy rate (around 80%) than NIPT but for me was accurate. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Based on the results of the NIPT test, your obstetrician may recommend diagnostic tests. My Hi all,I had my first NIPT labs drawn around 10 weeks. Your provider obtains a blood sample through a vein in your arm. They didn't even bother to retest mine when the first try came back inconclusive because they assumed it wouldn't work since I'm obese. I have read this is an issue for plus size women and . Had to redraw today and start the waiting process all over. My anatomy scan is the 16th so praying everything will come back normal. I've seen a few posts about on this sub from women who had insufficient fetal DNA because of their weight and had to go back for another draw. Both said due to low fetal DNA at 2.6% and 2.7% respectively. Most NIPT tests screen for: An extra chromosome causes Down syndrome, trisomy 18 and trisomy 13. hYmo6+bDR$EE iZcKZ2,5V~b)%7QGx{8qfs&,9K dbyb:,Xg1cekX3)-l`Gj%SV0H@1#43*a?+V1bM4^%}*&29Li1I=&~~K&a/e2,VaLFEZE]&7_4NO\Vq9z2.U\b1)0[$@'NmY=B(db~O^6jRJfbZ&\fMeY?RPu A]LaR2rt$\.E=_&ShK+05}rYo"&7xJ|10&,*NOop;~\@`zPd40`Qq[BlJMOnsgU*|]yepYE.+yf Theres also the possibility that no test results are given due to insufficient fetal DNA in your blood or difficulty identifying fetal DNA. Thank you! k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. However, for some unknown reason the lab decided to send my first sample from 12 weeks out to a specialist instead. Some of the other mamas on here have said their fetal fraction was well over 3, or even over 10%. Yes, NIPT can be done anytime after 10 weeks of pregnancy. Anyone have wrong gender results? I also have a bloodclot that I am on Lovenox for which adjust my blood levels, could this effect these results? So I'm not sure how it was for you. Theyre not sure what caused the inconclusives, but theyre screening and not diagnostics, so it could just be in error. This test can be done beginning at 10 weeks of pregnancy. Strangely enough, I am also on lovenox.I am also old at 39 and have a higher BMI. The #1 app for tracking pregnancy and baby growth. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know . Inconclusive NIPT result twice w wjhall I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. So I just found out that my NIPT came back with low fetal fraction for the second time. I pray that everything is good with your little one, if your scans looks good then there is a lot of hope that its all going to work out for you! Or chromosomes? My BMI is a bit high and I've read that can be a reason. I will likely decline invasive testing like amniocentesis. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Also at 13w3days I had my. *_xCeEm Di?z&>#m`X_ )= Create an account to follow your favorite communities and start taking part in conversations. So after 9 weeks of genetic testing and no results we were finally able to get results and everything has turned out ok and we are having a baby boy! I was super annoyed, but Im taking her word and hoping all is fine. H Hawaiimomma22 Nov 30, 2017 at 12:44 AM @veneziana, A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. What is noninvasive prenatal testing and what disorders can it screen for? :). , I am 27, 5' 3" and usually 150lbd to 155lbs maybe its a weight thing, idk hoping good news when the doctors calls, I think I will opt out of noninvasive too. 4% at least is needed for accuracy. I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. Both said due to low fetal DNA at 2.6% and 2.7% respectively. Use of this site is subject to our terms of use and privacy policy. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). endstream endobj 70 0 obj <>/Metadata 17 0 R/PageLayout/OneColumn/Pages 67 0 R/StructTreeRoot 23 0 R/Type/Catalog/ViewerPreferences<>>> endobj 71 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 72 0 obj <>stream On my NIPT scan the radiologist made a comment that some measurements I had were unclear. We strive to provide you with a high quality community experience. Would knowing this information help my provider(s) take better care of the baby? Yes, NIPT can predict the sex of the fetus. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Theres typically not enough fetal DNA in a pregnant persons blood before 10 weeks of pregnancy. NIPT testing is optional. I had the test done again about 2 weeks later and just got results today. 2005-2023Everyday Health, Inc., a Ziff Davis company. I'm sorry you weren't told! Sample did not meet the threshold for quality control.. I had a redraw last week and waiting for that to come back. The NIPT test is also called cell-free DNA (cfDNA) screening or noninvasive prenatal screening (NIPS). Hey! Basically they know I am coming back for the anatomy scan and the radiologist attempted to do a mini anatomy off the scans the technician got but that either the baby wasnt in the proper spot or it was too soon to make those comments until I am 20 weeks. Inconclusive just means they couldn't get a reading. Its soo nerve breaking!! I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. Please specify a reason for deleting this reply from the community. Many factors may go into your decision to have NIPT and prenatal genetic testing in general. Are you doing the NT scan & bloods as well? My nipt/panorama/harmony results came back inconclusive both times. Another inconclusive result. I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. Im so so sorry to hear about your loss. Inconclusive NIPT results twice : hello, just wondering if this has happened to anyone? Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. They kinda downplayed it saying it happens a lot, but it still stresses me out a little. (https://www.smfm.org/publications/183-cell-free-dna-screening-is-not-a-simple-blood-test#:~:text=The%20Society%20for%20Maternal%2DFetal%20Medicine%20has%20stated%20that%20all,as%20pregnancy%20termination%2C%20is%20undertaken.). That is heartbreaking. Yes please do let me know what helped you. My Hi all,I had my first NIPT labs drawn around 10 weeks. You may have questions about what your results mean or if you should even have the NIPT test. thank you - apparently triploidy is not linked to maternal age - Im 29 and it could have happened to an 18 year old or a 40 year old mother. Are there other tests I can take to find out my risks? Its a personal choice, and its normal to have questions. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. My anatomy ultrasound is on Friday. Maybe call the clinic directly for feedback on how that particular radiologist writes reports. I can send you in the right direction. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. E@Gpc 8Op!ISHiT7{;-N/OM7Mq+YV1d)|\i-V;`]tyTAHqAFWR I had inconclusive NIPT results. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Has anyone had this happen to them or know someone? We will not be doing anymore testing for baby boy #3. My first pregnancy resulted in a miscarriage at 8 weeks. Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. I was also severely anemic and dehydrated due to hyperemesis gravidum. The result will show if theres an increased or decreased risk for a fetus to have the condition being screened. Could it be a false positive? NIPT is a screening test, which means that it wont give a yes or no answer about whether or not a fetus has a condition. X. I am overweight. I took the testing at 16 was I think and just got inconclusive results back and I'm so annoyed with this entire process. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. . He sent me to do echocardiography which also was good and show no signs for pathologies. There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. My doc told me 2 inconclusive tests raises the risk level significantly in my age. Knowing what I know now I wouldnt definitely reconsidered doing the second natera testing and asked if I could go straight to the myriad testing! I am now 25 weeks. Also, all of the anatomy scans have come back perfect. Whether patients are referred to us or already have a Cleveland Clinic ob/gyn, we work closely with them to offer treatment recommendations and follow-up care to help you receive the best outcome. I am way larger than you. I am so confused and stressed. Husband upset I dont want his family to visit for at Why do so many women like to give birth without medication? - May 2020 Babies | Forums | What to Expect Community > Birth Month May 2020 Babies 97K Discussions 192K Members The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. This test can also provide information about the sex of the fetus. 1997-2023 BabyCenter, LLC, a Ziff Davis company. I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. Your post will be hidden and deleted by moderators. hbbd``b` $X-  H *H2M) u$B@> LW@b!3.|` Last reviewed by a Cleveland Clinic medical professional on 10/12/2022. It is super frustrating, and I think honestly more frustrating that docs continue to recommend these tests when it seems like everyone I know with a high BMI had this issue. Oh overall not just gender lol I wish it were twins but I already had a few ultrasounds and saw the single baby. Just want to complain somewhere. I do think that its such a fighter since it lasted so long fingers crossed its healthy. Trying not to worry.but I am. Ocean/sky themed baby girl nursery - finished at 38+ A hilarious moment that made me excited to have my kid. Its nerve racking, but I'm hoping to hear some good news soon. My risk just due age is 1/94 for trisomy 13, 18. Even though my OB told me it likely wasn't the case for me, I was still in panic mode for a while. Talk to your healthcare provider or a genetic counselor about your concerns. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. Press J to jump to the feed. All rights reserved. The accuracy of the test varies by the condition that its checking for. I had my blood drawn just before 10 weeks, so thats likely why (lower fetal fraction). We offer women's health services, obstetrics and gynecology throughout Northeast Ohio and beyond. However, its now recommended that providers offer NIPT to all pregnant people, regardless of risk. Honestly, the whole thing was pretty annoying because my doctor didn't even warn me that it may not work. This educational content is not medical or diagnostic advice. It set my expectations unreasonably high. I dont have any advice. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. I am assuming they will suggest more invasive testing? So bizarre this happens. Your test results may sometimes be hard to interpret, so ask your healthcare provider for help if youre unsure. The first rest was done around 10 weeks and the second around 14 weeks. Learn more about, Twins & Multiples: Your Tentative Time Table. Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. It's normal. 2005-2023Everyday Health, Inc., a Ziff Davis company. Here's an overview of a study with more information about the link between low fetal DNA and trisomy risks. I have a CVS booked for this Thursday which should give me definitive results but both scans didnt look good so far. Has this happened to anyone? They could have also just waited until 16 weeks for my first blood draw given my weight. If you dont have insurance or your insurance doesnt cover NIPT tests, you can pay for the test. When I went back for a second blood draw, they took two tubes of blood. Good luck to you! Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. My doctor told me to test then and acted as if that wasnt too early. I found out we are having a little girl! As far as 16 weeks ultrasound, sex was pretty obvious on mine . Create an account or log in to participate. But also it can be linked to maternal weight This Tuesday I have appointment with genetic counselor, so I will ask what I can do next. Taylor-Phillips S, Freeman K, Geppert J, et al. The first time it came back inconclusive due to low fetal fraction. I am so sorry this has happened twice! Overall, NIPT tests produce fewer false positives than other prenatal screenings like the quad screen. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Mumsnet carries some affiliate marketing links, so if you buy something through our posts, we may get a small share of the sale (more details here). Are you going to go for a CVS? Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Create an account or log in to participate. Your post will be hidden and deleted by moderators. . I think if the scan/bloods come back clear then I wont do a third one (just more worry/waiting) but if there is anything not good I will have to decide to either do a third NIPT or more invasive procedures (which I would really want to avoid!). It just means they don't have enough information to make any kind of conclusion. Low Fetal Fraction. @Woofwoofbarkbark ya I definitely want to know as early as possible, t13/t18 have such such high chance of late miscarriage etc I need to be prepared if this was a chance To comment on this thread you need to create a Mumsnet account. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. You apparently have too much blood for an accurate reading. Had my redraw at 13+2, and results have come back the same, inconclusive due to low fetal fraction. I'll be around 18 weeks by then. The NIPT looks at these fragments of fetal DNA in your blood known as cell-free DNA or cfDNA. , I agree with PP. Praise post for amazing husbands and good in-laws. I met with a genetics counselor and decided to do a 3rd round of genetic testing through Myriad! Many cover at least a portion. Advertising on our site helps support our mission. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. NIPT stands for noninvasive prenatal testing. Now it is considered high risk and listed a 1/17 chance of a chromosome issue. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Diagnostic testing may be recommended after you get NIPT test results. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. Yes, Harmony is NIPT. Inconclusive NIPT results. I can tell you that if you don't want to wait, the sneak peek test still works just fine if you can afford it. %%EOF I didn't even want them to do that. Now at 16w they were both under 2. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm).

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